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We review the role of cadherins and cadherin-related proteins in human cancer.

Cellular and animal models for human cancer are also dealt with whenever appropriate.

Here we discuss the structural and functional aberrations of cadherin family members in cancer and their roles in cancer initiation and progression.Its prototypic member, E-cadherin, was characterized as a potent suppressor of invasion and metastasis in seminal studies dating back to the 1990s (reviewed by van Roy and Berx 2008).Since then, many more cadherins and cadherin-related proteins have been identified (Fig.The atypical T-cadherin/CDH13 is often silenced in cancer cells but up-regulated in tumor vasculature.The review also covers the status of protocadherins and several other cadherin-related molecules in human cancer.

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